This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Topic Collections  • Radiation Therapy  • Women's Health  • Women's Health, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Cause for Concern or Opportunity for Future Research?

William Small, Jr, MD; Lisa Kachnic, MD

JAMA. 2005;294:2635-2637.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Radiotherapy has proven to be an indispensable tool in the curative management of malignant disease, especially for primary carcinomas of the pelvis including prostate, rectal, cervical, endometrial, and anal cancers. In this setting, radiotherapy is used either alone or in combination with systemic, hormonal, and/or surgical therapies. The ultimate goal of this radiation-based therapy is to provide long-term disease control or a "cure" with as little treatment-related morbidity as possible. Yet, the study of long-term toxicity associated with treatments that include radiation therapy has received little attention over the years.

Radiation toxicity can roughly be divided into early and late effects. Early or acute effects, such as nausea, skin reactions, diarrhea, and neutropenia, tend to be temporary and, for the most part, resolve shortly after the completion of therapy. Late effects, such as connective tissue fibrosis and secondary malignancies, can occur long after . . . [Full Text of this Article]

Author Affiliations: Division of Radiation Oncology, Northwestern University, Chicago, Ill (Dr Small); Department of Radiation Oncology, Boston University Medical Center, Boston, Mass (Dr Kachnic).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Risk of Pelvic Fractures in Older Women Following Pelvic Irradiation
Nancy N. Baxter, Elizabeth B. Habermann, Joel E. Tepper, Sara B. Durham, and Beth A. Virnig
JAMA. 2005;294(20):2587-2593.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A murine model for bone loss from therapeutic and space-relevant sources of radiation
Hamilton et al.
J. Appl. Physiol. 2006;101:789-793.
ABSTRACT | FULL TEXT