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edited by M. Flint Beal, Anthony E. Lang, and Albert Ludolph, 985 pp, with illus, $400, ISBN 0-521-81166-X, New York, NY, Cambridge University Press, 2005.

JAMA. 2005;294:2640-2641.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Neurodegenerative Diseases is one of the most comprehensive books to appear on the subject in the past decade. There are more focused texts, such as the excellent and well-written Neurodegenerative Dementias, edited by Clark and Trojanowski, Molecular Mechanisms of Neurodegenerative Diseases, edited by Chesselet, and Pathogenesis of Neurodegenerative Disorders, edited by Mattson. But, unlike them, Neurodegenerative Diseases discusses all the neurodegenerative illnesses, with special attention to biological, pathophysiological, clinical, and therapeutic aspects, rather than focusing on a single facet.

The first section is devoted to the basic science of neurodegeneration and the way it figures in the pathogenesis of neurodegenerative disorders. The content is thorough enough to satisfy the most hard-core of basic scientists, yet is written with enough clarity and fluidity to be helpful to uninitiated clinicians. The most intriguing chapter in this section is "The Role of Inflammation in Alzheimer’s Disease" (AD), by Giulio Pasinetti, which discusses . . . [Full Text of this Article]

Hrayr Attarian, MD, Reviewer
University of Vermont Medical School
Burlington
hattaria@uvm.edu

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