This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Oncology  • Colon Cancer  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In Reply: Dr Vachon suggests that possible differences in socioeconomic status or race might explain a reduced risk of colorectal cancer among aspirin users. However, the likelihood for such confounding is low in an occupationally homogeneous cohort such as the Nurses' Health Study. In addition, the percentage of nonwhite women in the cohort was low across all aspirin groups (1%-3%) and, thus, could not explain the magnitude of our associations. In analyses restricted to white women, our results were not materially different. Compared with women who denied any aspirin use, the multivariate relative risks for cancer were 1.08 (95% confidence interval [CI], 0.89-1.33) for women who used 0.5 to 1.5 standard aspirin per week, 0.83 (95% CI, 0.66-1.05) for 2 to 5 aspirin per week, 0.71 (95% CI, 0.55-0.92) for 6 to 14 aspirin per week, and 0.64 (95% CI, 0.43-0.94) for more than 14 aspirin per week (P . . . [Full Text of this Article]

Andrew T. Chan, MD, MPH
achan@partners.org
Massachusetts General Hospital
Boston

Charles S. Fuchs, MD, MPH
Dana-Farber Cancer Institute
Boston, Mass

RELATED ARTICLES

Long-term Use of Aspirin and Risk of Colorectal Cancer
Gregory C. Vachon
JAMA. 2005;294(24):3090.
EXTRACT | FULL TEXT  

Long-term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs and Risk of Colorectal Cancer
Andrew T. Chan, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Eva S. Schernhammer, Gary C. Curhan, and Charles S. Fuchs
JAMA. 2005;294(8):914-923.
ABSTRACT | FULL TEXT