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Biomarkers for Mortality and Cardiovascular Events—Reply
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In Reply: Dr Koenig states that a potential high prevalence of diastolic dysfunction in our older population might favor NT-proBNP as a risk marker compared with CRP and urinary albumin/creatinine ratio. We found that NT-proBNP predicted development of heart failure and, as noted in our article, this finding may in part be explained by the presence of undetected diastolic dysfunction. We agree that the predictive value of biomarkers in the general population should be investigated in individuals without apparent cardiovascular disease. Accordingly, participants with prevalent ischemic heart disease and previous ischemic stroke were excluded from the analyses of major cardiovascular events. Our finding that NT-proBNP is also a strong predictor in these individuals without cardiovascular disease is consistent with data from the Framingham Heart Study, which investigated BNP as a risk marker in a younger community-based cohort.1
Koenig correctly points out that CRP levels are influenced by the use of . . . [Full Text of this Article]
Caroline Kistorp, MD
cnkistorp@dadlnet.dk
Ilan Raymond, MD, PhD;
Frants Pedersen, MD, PhD
Frederiksberg University Hospital
Copenhagen
Finn Gustafsson, MD, PhD
State University Hospital, Rigshospitalet
Copenhagen
Jens Faber, MD, DMSc
Herlev University Hospital
Herlev
Per Hildebrandt, MD, DMSc
Frederiksberg University Hospital
Copenhagen, Denmark
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Biomarkers for Mortality and Cardiovascular Events
Wolfgang Koenig
JAMA. 2005;294(3):303.
EXTRACT
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N-Terminal Pro-Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels as Predictors of Mortality and Cardiovascular Events in Older Adults
Caroline Kistorp, Ilan Raymond, Frants Pedersen, Finn Gustafsson, Jens Faber, and Per Hildebrandt
JAMA. 2005;293(13):1609-1616.
ABSTRACT
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