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MicroRNAs Move Into Cancer Research
Tracy Hampton, PhD
JAMA. 2005;294:411-412.
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With the goal of understanding and manipulating the behavior of cells gone awry, many cancer researchers have turned to the gene-silencing technique known as RNA interference with the hope of using the approach to effectively mute the expression of genes that drive malignancies. Now, three new studies in the June 9 issue of Nature point to naturally occurring roles of interfering RNAs called microRNAs in cancer development, findings that could one day lead to new diagnostics and therapies.
The studies "change the landscape of cancer genetics," wrote Paul Meltzer, MD, PhD, of the National Human Genome Research Institute, in Bethesda, Md, in an accompanying News and Views article (Meltzer. Nature. 2005;435:745-746).
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Tiny, naturally occurring bits of RNA called microRNAs can play a role in cancer. When scientists injected cells expressing certain microRNAs into mice, fluorescence revealed that tumors arose more quickly and were more disseminated (left) . . . [Full Text of this Article] |
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A POTENTIAL RNA ONCOGENE
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