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In Search of the Holy Grail of Surrogate End Points

Mitchell S. Anscher, MD

JAMA. 2005;294:493-494.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Adenocarcinoma of the prostate is the most commonly diagnosed malignancy in men in the United States. It is estimated that, in 2005, 232 000 new cases will be diagnosed and 30 350 men will die from this disease.¹ Even though prostate-specific antigen (PSA) screening has not been conclusively demonstrated to reduce mortality from prostate cancer, this practice has been widely adopted in the United States. As a result, more patients are being diagnosed at a younger age and with disease localized to the prostate.^1-2 For these patients, radical prostatectomy (RP) and radiation therapy (RT) remain the mainstays of curative therapy.³ Nevertheless, prostate cancer remains primarily a disease of older men, many of whom have other serious coexisting illnesses from which they may be far more likely to die. Thus, it remains a major challenge for the clinician to identify which patients need aggressive treatment and which do not.

. . . [Full Text of this Article]

Author Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, NC.

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