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Human Skeletal Muscle as a Target Organ of Trichloroethylene Toxicity
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To the Editor: Trichloroethylene (TCE) is widely used as a metal degreaser, dry cleaning solvent, spot remover, adhesive, lubricant, and anesthetic and analgesic agent.1 In humans, it can induce acute toxicity, most commonly in the kidney, liver, and central nervous system.2 Most TCE toxicity depends on bioactivation by either cytochrome P450–dependent oxidation or glutathione conjugation.2 We are not aware of previous reports of human skeletal muscle damage after acute poisoning by TCE.
Case Report
A man in his 40s was admitted to the intensive care unit about 3 hours after oral ingestion of an unknown amount of TCE in a suicide attempt. He was in good physical condition before ingestion but presented with a Glasgow Coma Scale rating of 3, hypotension, sinus tachycardia, and severe diarrhea with normal-colored stool with an odor of TCE. Because of acute respiratory failure, he underwent tracheal intubation and mechanical ventilation. On the fourth day of hospitalization, . . . [Full Text of this Article]
Gaetano Vattemi, MD, PhD;
Paola Tonin, MD;
Massimiliano Filosto, MD, PhD;
Nicolò Rizzuto, MD;
Giuliano Tomelleri, MD
giuliano.tomelleri@univr.it
Department of Neurological Sciences and Vision
Section of Clinical Neurology
Luigi Perbellini, MD
Institute of Occupational Medicine
University of Verona
Verona, Italy
Walter Iacovelli, MD;
Nicola Petrucci, MD
Department of Anesthesia and Intensive Care
Azienda Ospedaliera Desenzano
Desenzano, Italy
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