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Accumulating Evidence for Prenatal Nutritional Origins of Mental Disorders
Richard Neugebauer, PhD, MPH
JAMA. 2005;294:621-623.
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The study by St Clair et al1 in this issue of JAMA reports an association between prenatal exposure to severe maternal nutritional deficiency and risk for schizophrenia in adulthood. Examination of this question was achieved through strategic use of the Chinese famine of 1959 through 1961 as the fulcrum of their study design. In so doing, these authors afford yet another excellent example, frequent among articles in the annual JAMA theme issue on violence and human rights, of epidemiologists extracting otherwise inaccessible scientific knowledge from the harsh soil of human catastrophe.
Susser and Lin2 were the first to demonstrate this link between severe maternal nutritional deficiency and the offsprings’ risk for schizophrenia. That earlier study, which served as the scientific impetus and analytic model for the current investigation, examined the association between nutrition and schizophrenia using the unique circumstances created by the Dutch Hunger Winter of . . . [Full Text of this Article]
Author Affiliations: Epidemiology of Developmental Brain Disorders Department, New York State Psychiatric Institute; Faculty of Medicine, College of Physicians and Surgeons, Columbia University, New York; and Department of International Health and Development, School of Public Health and Tropical Medicine, Tulane University, New Orleans, La.
RELATED ARTICLE
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
David St Clair, Mingqing Xu, Peng Wang, Yaqin Yu, Yourong Fang, Feng Zhang, Xiaoying Zheng, Niufan Gu, Guoyin Feng, Pak Sham, and Lin He
JAMA. 2005;294(5):557-562.
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