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Bridget M. Kuehn

JAMA. 2005;294:887-889.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Forty years and countless political firestorms after it was first introduced, methadone maintenance for the treatment of opioid addiction remains a standard therapy in the field of addiction treatment.

The publication on August 23, 1965, of positive results from a small clinical trial of methadone as a treatment for heroin addiction in JAMA marked a sea change in the treatment of addiction (Dole and Nyswander. JAMA. 1965;193:646-650). The study, conducted at Rockefeller University in New York City by Vincent P. Dole, MD, and the late Marie E. Nyswander, MD, suggested that a medication could be used to control the cravings and withdrawal that often lead to relapse in individuals with opioid addiction who attempt to quit.

The work, along with subsequent research by Dole, an endocrinologist, Nyswander, a psychiatrist, and colleagues established the concept of opioid addiction as a chronic disease, similar to diabetes, that as . . . [Full Text of this Article]

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