 |
|
Can a Potent Statin Actually Regress Coronary Atherosclerosis?
Roger S. Blumenthal, MD;
Navin K. Kapur, MD
JAMA. 2006;295:(doi:10.1001/jama.295.13.jed60019).
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
Since the initial report by Sones and Shirey in 1962,1 coronary angiography has been the standard method used to define the severity and extent of coronary atherosclerosis. By only providing a silhouette of the coronary lumen, however, coronary angiography frequently underestimates the true burden of atheroma in the arterial wall. In this issue of JAMA, Nissen et al present important new data on coronary atherosclerosis based on their findings from the ASTEROID (A Study To Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) trial.2 This multicenter, intravascular ultrasound (IVUS) study assessed the extent of coronary atheroma at baseline and after 2 years of treatment with the maximally approved dose (40 mg) of rosuvastatin, the statin most effective at reducing levels of low-density lipoprotein cholesterol (LDL-C). Each pair of baseline and 24-month IVUS studies was analyzed in blinded fashion.
. . . [Full Text of this Article]
Author Affiliations: The Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Md.
RELATED ARTICLE
Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis: The ASTEROID Trial
, , , , , , , , , , , , , , , , and
JAMA. ;295():1556-1565.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice
Glaros et al.
J. Lipid Res. 2008;49:324-331.
ABSTRACT
| FULL TEXT
Atherosclerosis Regression, Vascular Remodeling, and Plaque Stabilization
Klein
J Am Coll Cardiol 2007;49:271-273.
FULL TEXT
High-Intensity Statin Therapy Leads to Regression of Coronary Atherosclerosis
JWatch Emergency Med. 2006;2006:3-3.
FULL TEXT
High-Intensity Lipid Lowering Reduces Atheroma Volume
Journal Watch Cardiology 2006;2006:5-5.
FULL TEXT
|
