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Michael L. Dansinger, MD, MS; Ernst J. Schaefer, MD

JAMA. 2006;295:94-95.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The article by Howard and colleagues¹ in this issue of JAMA, which reports on the largest, most ambitious randomized dietary intervention trial conducted to date, has concluded that a low-fat diet program does not produce weight gain.¹ Despite the impressive features of this landmark study, the findings on long-term weight change are somewhat underwhelming.

The Women's Health Initiative (WHI),² of which the Dietary Modification Trial is one component,³ is one of the most outstanding achievements in clinical research history. The National Institutes of Health established the WHI in 1991 to address the most common causes of death, disability, and impaired quality of life in postmenopausal women. This multimillion-dollar, 15-year project, involving 161 808 women aged 50 through 79 years, was designed to address many of the inequities in women's health research and provide practical information to women and their physicians about . . . [Full Text of this Article]

Author Affiliations: Division of Endocrinology, Diabetes, and Metabolism, Tufts-New England Medical Center (Dr Dansinger); and Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Dr Schaefer), Boston, Mass.

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Low-Fat Dietary Pattern and Weight Change Over 7 Years: The Women's Health Initiative Dietary Modification Trial
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