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Placental Weight and Maternal Risk of Breast Cancer—Reply
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In Reply: We agree with Dr Murray that there is good evidence that parity protects against breast cancer, since nulliparous women are at a higher risk of developing breast cancer compared with parous women.1 This risk is further reduced, although more modestly, with each subsequent birth.2 We do not think that our results are inconsistent with these findings.
Because our a priori hypothesis was that placental weight influences maternal breast cancer risk, the study population only included parous women. Within this cohort of parous women, we observed a protective effect of increasing parity with respect to breast cancer risk. Compared with women who had only 1 birth between 1983 and 2001, women with at least 3 births had a reduced risk of breast cancer, with and without adjustment for placental weight and other covariates (adjusted odds ratio, 0.77; 95% confidence interval, 0.64-0.92). Thus, large placentas do not obliterate the relatively . . . [Full Text of this Article]
Sven Cnattingius, MD, PhD
sven.cnattingius@ki.se
Anna Torrång, BSc
Department of Medical Epidemiology and Biostatistics
Anders Ekbom, MD, PhD;
Fredrik Granath, PhD
Department of Medicine
Gunnar Petersson, BSc;
Mats Lambe, MD, PhD
Department of Medical Epidemiology and Biostatistics
Karolinska Institutet
Stockholm, Sweden
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