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To the Editor: Shyness and social anxiety are reported in women with Turner syndrome (TS).¹ Possible contributors include physical stigmata, such as short stature and neck-webbing, chromosomally-based deficits in social cognition, and premature ovarian failure with infertility. To investigate the potential role of premature ovarian failure and infertility, we compared measures of psychosocial distress in women with TS, women with spontaneous karyotypically normal premature ovarian failure (POF), and healthy controls.

Methods

Participants in this institutional review board–approved study were recruited through National Institutes of Health (NIH) Web sites and newspapers and provided written informed consent. Inclusion criteria for patients with TS and POF are described elsewhere.² Daily hormone therapy was taken by 99% of the women with TS and 90% with POF but was discontinued 2 weeks before evaluation.

Control participants were recruited from the local community and were paid a small stipend. They were required to have regular menstrual cycles, . . . [Full Text of this Article]

Peter J. Schmidt, MD
peterschmidt@mail.nih.gov

Graca M. P. Cardoso, MD
Behavioral Endocrinology Branch
National Institute of Mental Health
National Institutes of Health
Bethesda, Md

Judith L. Ross, MD
Department of Pediatrics
Thomas Jefferson University
Philadelphia, Pa

Nazli Haq, MA; David R. Rubinow, MD
Behavioral Endocrinology Branch
National Institute of Mental Health

Carolyn A. Bondy, MD
Developmental Endocrinology Branch
National Institute of Child Health and Human Development
National Institutes of Health
Bethesda, Md

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