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Tracy Hampton, PhD

JAMA. 2006;295:1503.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

For the first time a virus has been linked to the development of prostate cancer, a finding that lends support to previous studies suggesting that some prostate cancers may be caused by infection.

Research presented at the 2006 Prostate Cancer Symposium, cosponsored by the American Society of Clinical Oncology, the American Society for Therapeutic Radiology and Oncology, the Prostate Cancer Foundation, and the Society of Urologic Oncology, revealed that men with a genetic mutation in the Human Prostate Cancer 1 (HPC1) gene harbor this newly identified virus 30 times more frequently than men without the genetic mutation.

The HPC1 gene encodes an antiviral protein activated by viral infection, RNaseL. Variants of HPC1 that impair function of RNaseL have been proposed as susceptibility factors for prostate cancer. Men who have two copies of a mutated HPC1 gene have double the risk of developing prostate cancer compared with . . . [Full Text of this Article]