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Risk of Multiple Primary Melanomas
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To the Editor: Dr Ferrone and colleagues1 described the clinicopathological features of patients with multiple primary melanomas (MPMs) using a single institution's database. The study found that the incidence of MPM is increased in patients with a personal history of dysplastic nevi, a family history of melanoma, or both, and concluded that these patients should undergo intensive screening. There are some important issues that the article did not address.
The authors should clarify patient adherence to the follow-up regimens. A correlation between the incidence of melanomas and the degree of surveillance activity for melanoma has been observed.2-3 It is likely that patients with dysplastic nevi or a family history of melanoma or both had more careful scrutiny, which could account for some of the observed increased incidence of MPM in this subgroup.
Such effects are suggested by the large proportion (59%) of patients who had their second melanoma diagnosed within . . . [Full Text of this Article]
Aditya Bardia, MD, MPH;
Mark R. Pittelkow, MD;
Ravi D. Rao, MD
rao.ravi@mayo.edu
Mayo Clinic College of Medicine
Rochester, Minn
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RELATED ARTICLE
Clinicopathological Features of and Risk Factors for Multiple Primary Melanomas
Cristina R. Ferrone, Leah Ben Porat, Katherine S. Panageas, Marianne Berwick, Allan C. Halpern, Ami Patel, and Daniel G. Coit
JAMA. 2005;294(13):1647-1654.
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