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To the Editor: We recently reported that insulin resistance is an independent predictor of congestive heart failure (CHF).¹ In a subsequent Letter to the Editor, Stefan et al² proposed adiponectin as a mediator of that association. Low adiponectin concentration has been associated with risk of myocardial infarction.³ We therefore investigated in our cohort (Uppsala Longitudinal Study of Adult Men) whether circulating adiponectin (primary hypothesis) or single nucleotide polymorphisms (SNPs) in the adiponectin gene ADIPOQ (secondary hypothesis) predict incident CHF.

Methods

Frozen serum samples that had been collected during 1991 through 1995 from participants¹ were used to analyze circulating adiponectin and to genotype for SNPs in the ADIPOQ gene. Serum adiponectin was analyzed using an immunofluorometric assay.⁴ Genotyping was performed at the WCN (Wallenberg Consortium North, Stockholm, Sweden) SNP technology platform (Uppsala University, Uppsala, Sweden). The overall sample success rate was 95.9%, with an accuracy of 99.9% according to duplicate analysis of . . . [Full Text of this Article]

Erik Ingelsson, MD, PhD
erik.ingelsson@pubcare.uu.se

Ulf Risérus, MMed, PhD
Department of Public Health and Caring Sciences/Geriatrics
Uppsala University
Uppsala, Sweden

Christian Berne, MD, PhD
Department of Medical Sciences
Uppsala University
Uppsala, Sweden

Jan Frystyk, MD, PhD; Allan Flyvbjerg, MD, PhD
Medical Research Laboratories
Aarhus University Hospital
Aarhus, Denmark

Tomas Axelsson, PhD; Per Lundmark, MSc
Department of Medical Sciences
Uppsala University
Uppsala, Sweden

Björn Zethelius, MD, PhD
Department of Public Health and Caring Sciences/Geriatrics
Uppsala University
Uppsala, Sweden

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