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Tracy Hampton, PhD

JAMA. 2006;295:1886.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

An experimental vaccine made from an inactivated H5N1 avian influenza virus can induce immune responses in more than half of healthy adults tested, but requires 2 doses of vaccine each of which is 6 times the dose of that used in a standard influenza shot to have this effect, according to results of a randomized multicenter trial (Treanor JJ et al. N Engl J Med. 2006;354:1343-1351). The findings provide some hope for the control of a potential pandemic, but a more effective vaccine given at lower doses will be needed to meet the world's demands should such a pandemic occur.

In the first stage of the study, 118 healthy adults aged 18 to 64 years were randomly assigned to one of five groups: volunteers were injected with an initial dose of vaccine of 7.5 µg, 15 µg, 45 µg, or 90 µg or a saline placebo . . . [Full Text of this Article]