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To the Editor: Most patients with a chronic thyroid disease experience some sexual symptoms, including erectile dysfunction.¹ In their study, Dr Thompson and colleagues² found a significant association between erectile dysfunction and subsequent clinical cardiovascular events, but it does not appear that they considered the potential effect of thyroid disorders. Because patients with thyroid disease may have an increased cardiovascular risk,^3-5 the presence of thyroid hormone disorders might have confounded their results.

Financial Disclosures: None reported.

Luca Mascitelli, MD
lumasci@libero.it
Sanitary Service
Comando Brigata alpina "Julia"
Udine, Italy

Francesca Pezzetta, MD
Cardiology Service
Ospedale di San Vito al Tagliamento
San Vito al Tagliamento, Italy

1. Carani C, Isidori AM, Granata A, et al. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab. 2005;90:6472-6479. FREE FULL TEXT 2. Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005;294:2996-3002. FREE FULL TEXT 3. Nyirenda MJ, Clark DN, Finlayson AR, et al. Thyroid disease and increased cardiovascular risk. Thyroid. 2005;15:718-724. FULL TEXT | ISI | PUBMED 4. Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005;187:1-15. FREE FULL TEXT 5. Walsh JP, Bremner AP, Bulsara MK, et al. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med. 2005;165:2467-2472. FREE FULL TEXT

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295:1998-1999.

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