This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Midodrine is commonly prescribed for treatment of orthostatic hypotension.¹ We have been studying its use as a pharmacological countermeasure for post-spaceflight orthostatic hypotension because it is fast acting and has no known cardiac or central adverse effects.¹ Promethazine is the antiemetic of choice by National Aeronautics and Space Administration (NASA) flight surgeons for the treatment of postflight nausea and vomiting. Because midodrine and promethazine would likely be used together on landing day, we studied whether promethazine would counteract the positive effects of midodrine on orthostatic tolerance. In the course of that study, we observed an unexpected degree of akathisia.

Methods

Ten healthy participants were recruited from the general public by the Johnson Space Center Test Subject Facility. One withdrew from the study before testing. The remaining participants received all 4 possible sequences of treatment in random order, separated by at least 4 days. Treatment consisted of either midodrine, . . . [Full Text of this Article]

Steven H. Platts, PhD
Universities Space Research Association

Shang-Jin Shi, MD, PhD
Wyle Laboratories

Janice V. Meck, PhD
jmeck@ems.jsc.nasa.gov
Human Adaptation and Countermeasures Office
NASA Johnson Space Center
Houston, Tex

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?