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To the Editor: In their study of habitual caffeine intake and the risk of hypertension, Dr Winkelmayer and colleagues¹ analyzed data from a large population-based cohort study in US nurses. Total caffeine intake was associated with risk of hypertension in this study, but no relationship with consumption of caffeinated coffee was observed. Cola and other caffeinated soft drinks, however, appeared to increase blood pressure.

Findings from this study are compatible with a recent meta-analysis that we conducted, in which we combined data from randomized controlled trials to examine the effect of both coffee and caffeine on blood pressure.² When caffeine trials (n=7) and coffee trials (n=18) were analyzed separately, blood pressure elevations appeared to be 4 times greater for caffeine given as tablets (4.2 mm Hg systolic and 2.4 mm Hg diastolic) than for caffeinated coffee (1.2 and 0.5 mm Hg, respectively). These differences are not explained by caffeine dose: . . . [Full Text of this Article]

Johanna M. Geleijnse, PhD
marianne.geleijnse@wur.nl
Division of Human Nutrition
Wageningen University
Wageningen, the Netherlands

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