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How Thrombogenic Is Hypoxia?
Peter Bärtsch, MD
JAMA. 2006;295:2297-2299.
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On August 3, 1953, a US expedition consisting of 7 men got caught in prolonged storms at an altitude of about 8200 m on the Abruzzi ridge of K2, the second highest mountain in the world. After 4 days, venous thrombosis was diagnosed in the leg of Art Gilkey followed 2 days later by coughing and dyspnea, presumably due to pulmonary embolism. During the retreat from the mountain, the whole party started to slide down the steep ridge as their ropes became entangled. All were stopped by the strong hand of the last man.1
This well-known incident, other anecdotal reports from Himalayan climbers, and the finding of thrombi in the pulmonary vasculature of individuals who succumbed to high altitude pulmonary edema2 led to the notion that hypoxia must be thrombogenic. However, the question of whether the thrombi may have been a result rather than a cause of . . . [Full Text of this Article]
Author Affiliation: Abteilung Innere Medizin VII (Sportmedizin), Universitätsklinikum Heidelberg, Heidelberg, Germany.
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