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Offers Postexposure Protection in Monkeys

Tracy Hampton, PhD

JAMA. 2006;295:2346.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A new vaccine developed by scientists from the United States and Canada can prevent deadly hemorrhagic fever in monkeys after exposure to the Marburg virus, a naturally virulent pathogen that could also be manipulated for use as agents of bioterrorism (Daddario-DiCaprio KM et al. Lancet. 2006;367:1399-1404). Earlier research by the team demonstrated that the vaccine could prevent Marburg hemorrhagic fever from developing when given before infection (Jones SM et al. Nat Med. 2005;11:786-790), but these latest results suggest that the vaccine could also be an effective postexposure treatment.

Investigators led by Thomas Geisbert, PhD, of the US Army Medical Research Institute of Infectious Diseases, in Fort Detrick, Md, and Heinz Feldmann, MD, of the National Microbiology Laboratory at the Public Health Agency of Canada, in Winnipeg, Manitoba, created the vaccine by replacing a gene from the attenuated recombinant vesicular stomatitis virus (rVSV) with a gene . . . [Full Text of this Article]