This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on ISI (1)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • Musculoskeletal Syndromes (Chronic Fatigue, Gulf War)  • Alert me on articles by topic

Tracy Hampton, PhD

JAMA. 2006;295:2466-2467.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Despite more than 2 decades of research and several thousand peer-reviewed articles on chronic fatigue syndrome (CFS), a great mystery still shrouds this potentially debilitating condition. But now a series of studies on CFS links the condition to certain genes involved in the immune and stress responses.

The research, described in 14 articles published in the April issue of the journal Pharmacogenomics (http://www.futuremedicine.com/loi/pgs), "is the first credible evidence of a biological basis for chronic fatigue syndrome," said Julie Gerberding, MD, MPH, director of the Centers for Disease Control and Prevention (CDC), in Atlanta, Ga. Further research should determine whether the findings have potential for diagnosing or treating CFS, which occurs most commonly in white women and includes unexplained symptoms such as fatigue, pain, memory impairment, and sleep disorders.

New research has linked chronic fatigue syndrome with genes that have roles in the hypothalamic-pituitary-adrenal axis and . . . [Full Text of this Article]

COLLABORATIVE RESEARCH