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Radiosurgery and Whole-Brain Radiation Therapy for Brain Metastases
Either or Both as the Optimal Treatment
Jeffrey Raizer, MD
JAMA. 2006;295:2535-2536.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Brain metastases are the most feared and debilitating complication of systemic cancers. They affect approximately 170 000 patients a year, with the most common primary tumors being lung cancer, breast cancer, and melanoma.1 The traditional approach for patients with brain metastases has been whole-brain radiation therapy (WBRT), irrespective of lesion number or primary site.
A shift in treatment occurred for patients with a single brain metastasis after 3 randomized trials were completed.2-4 In these trials patients were randomized to receive WBRT alone or surgical resection of a single brain metastasis followed by WBRT. In studies by Patchell et al2 and Noordijk et al,3 resection of a single brain metastasis prior to WBRT led to an increase in median survival of 25 and 17 weeks, respectively. There was also a significant increase in functionality for the surgical group in both studies. A study by Mintz et al4 did not . . . [Full Text of this Article]
Author Affiliation: Feinberg School of Medicine, Northwestern University, Chicago, Ill.
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