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Reconciling Apparently Contradictory Results

Roger J. Lewis, MD, PhD; James T. Niemann, MD

JAMA. 2006;295:2661-2664.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Out-of-hospital sudden cardiac death is a major health problem. According to Becker et al,¹ in summarizing the 2000 Pulse Conference, "We lose more than 1000 lives each day in the United States from sudden, unexpected death, a fatality rate comparable to the crash of two 747 aircraft without survivors." To make matters worse, current interventions for the treatment of nontraumatic cardiopulmonary arrest, conforming to a "chain of survival" concept, have not significantly improved neurologically intact survival rates over a decade.^2-3 The overall survival rate is less than 5% and the chance of normal neurological function is even lower.

The considerations in resuscitation research can be conceptualized using a 3-phase model for resuscitation after cardiac arrest.⁴ In the first or electrical phase, immediate defibrillation of ventricular fibrillation, if present, is most likely to result in survival. To this end, the development of . . . [Full Text of this Article]

Author Affiliations: Department of Emergency Medicine and Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles Medical Center, Torrance; and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.

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