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Atypical Antipsychotic Drugs, Dementia, and Risk of Death
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To the Editor: The systematic review of risk of death with atypical antipsychotic drug treatment for dementia by Dr Schneider and colleagues1 suggested that frail individuals who are exposed to this class of drugs may have increased mortality. Although the cause of death was not identified, this observation warrants further investigation.
A recent quality review of patients admitted to our hospital system with rhabdomyolysis found a surprisingly high incidence of quetiapine use among these patients. We performed a 9-month prospective review of all patient cases of rhabdomyolysis with creatine kinase of more than 5000 IU. The most common etiologies among 110 cases of rhabdomyolysis were trauma and compression (42%), drug or alcohol use (27%), shock (9%), and statin use (13%). Among the other causes, 6 cases were attributed to quetiapine, which was the most commonly associated drug in the series other than statin therapy. The average dose was 160 mg/d. . . . [Full Text of this Article]
Harminder Sikand, PharmD;
Joyce Jaojoco, PharmD;
Leslie Linares, MD;
Paul S. Phillips, MD
phillips.paul@scrippshealth.org
Scripps Mercy Hospital
San Diego, Calif
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