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Aman U. Buzdar, MD

JAMA. 2006;295:691-692.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Breast cancer is the second most common cancer in the world and the most common cancer among women in the United States and in other Western countries.¹ The incidence rate is about 5 times higher in Western countries than in developing countries.² Measurable success in multifaceted approaches for prevention and treatment has reduced breast cancer mortality in the United States and in a number of Western countries.³ These approaches include mammography screening, identification of very high-risk families with deleterious mutations within the BRCA1 and BRCA2 genes, and optimal use of adjuvant therapies with endocrine agents, chemotherapeutic agents, and biologically targeted therapy in patients with ERBB2-positive (HER2) disease.^4-7 A woman's risk of developing breast cancer in the next few years and/or her lifetime risk can be estimated using risk assessment tools.⁸ In women at risk of developing breast cancer, pharmacological interventions with antiestrogens (tamoxifen . . . [Full Text of this Article]

Author Affiliation: Department of Breast Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston.

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