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John D. Boice, Jr, ScD

JAMA. 2006;295:1060-1062.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Thyroid cancer was the first solid tumor reported to be increased in frequency among atomic bomb survivors.¹ Subsequent surveys found a significant excess of papillary thyroid cancer but not of follicular, medullary, or anaplastic cancer.^2-3 A straight line adequately describes the relationship between radiation dose and thyroid cancer incidence, relative risks are similar in males and females, and age at exposure substantively influences risk. Risk is highest for children exposed when younger than 10 years, and there is no significant increase in risk of thyroid cancer for those exposed after age 20 years. Radiation-induced thyroid cancers are rarely fatal, but the risk per unit dose following exposure in childhood is higher than for any other radiation-induced malignancy.⁴

Radiation-induced thyroid cancer has been extensively studied in human populations other than atomic bomb survivors. These populations include patients treated with radiation for malignant and nonmalignant conditions, populations . . . [Full Text of this Article]

Author Affiliations: International Epidemiology Institute, Rockville, Md, and Vanderbilt University School of Medicine, Nashville, Tenn.

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