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Tracy Hampton, PhD

JAMA. 2006;296:32.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

While vitamin E's antioxidant properties suggest that it may provide potential health benefits, there are conflicting findings about the medicinal value of vitamin E supplementation beyond the recommended daily allowance. Scientists have found, for example, that the nutrient has potential to benefit the immune system and prevent various diseases, but taking high doses also increase risks for bleeding problems.

Now, in new work that has yielded information adding weight to the positive side of vitamin E's balance sheet, researchers have discovered how a derivative of vitamin E can kill cancer cells and have used the information to make the derivative better (Shiau CW et al. J Biol Chem. 2006;281:11819-11825).

Researchers have found that structurally altering vitamin E succinate (blue) improves the agent's ability to kill cancer cells by about 5-fold in the laboratory. (Credit: Ching-Shih Chen, PhD/The Ohio State University)

"We found a mode of mechanism . . . [Full Text of this Article]

INDUCING APOPTOSIS

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Vitamin E Succinate Induces Ceramide-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma In vitro and In vivo
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ABSTRACT | FULL TEXT