You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 296 No. 10, September 13, 2006 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Commentary
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (19)
 •Contact me when this article is cited
 Related Content
 •Related letters
 •Similar articles in JAMA
 Topic Collections
 •Statistics and Research Methods
 •Randomized Controlled Trial
 •Prognosis/ Outcomes
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Moderators of Treatment Outcomes

Clinical, Research, and Policy Importance

Helena C. Kraemer, PhD; Ellen Frank, PhD; David J. Kupfer, MD

JAMA. 2006;296:1286-1289.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

For the last half-century, randomized clinical trials (RCTs) have been the "gold standard" of evaluating the efficacy or effectiveness of clinical interventions. Randomized clinical trials are based on well-recognized principles1 that underlie guidelines, such as the CONSORT (Consolidated Standards of Reporting Trials),2-4 for reporting such studies. As frequently happens when practices become routine, the underlying logic fades into the background. This increasingly appears to be the case with RCT methodology. Even the best performed RCTs often fail to provide information most crucial to evaluating the treatment under study and thus to improving medical decision making.

Two concerns stand out: statistical vs clinical significance and the heterogeneity of effect sizes. The first problem is well recognized and can be dealt with by requiring that a clinically interpretable effect size always be reported. Perhaps the most clinically meaningful effect size is . . . [Full Text of this Article]

RCT Methods and Interpretations

Author Affiliations: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif (Dr Kraemer); Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pa (Drs Frank and Kupfer).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

RELATED LETTERS

A Word From Our Moderator
Japp Deinum and Gert Jan van der Wilt
JAMA. 2007;297(2):156.
EXTRACT | FULL TEXT  

A Word From Our Moderator
Ian Shrier
JAMA. 2007;297(2):156-157.
EXTRACT | FULL TEXT  

A Word From Our Moderator—Reply
Helena C. Kraemer, Ellen Frank, and David J. Kupfer
JAMA. 2007;297(2):157.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Trials Design Lessons From the CATIE Study
Kraemer et al.
Am. J. Psychiatry 2009;166:1222-1228.
ABSTRACT | FULL TEXT  

Differential effects of daily snack food intake on the reinforcing value of food in obese and nonobese women
Temple et al.
Am. J. Clin. Nutr. 2009;90:304-313.
ABSTRACT | FULL TEXT  

Effectiveness of Lifestyle Physical Activity Interventions to Reduce Cardiovascular Disease
Dunn
AMERICAN JOURNAL OF LIFESTYLE MEDICINE 2009;3:11S-18S.
ABSTRACT  

Translating Scientific Opportunity Into Public Health Impact: A Strategic Plan for Research on Mental Illness
Insel
Arch Gen Psychiatry 2009;66:128-133.
ABSTRACT | FULL TEXT  

Dietary Restraint and Telomere Length in Pre- and Postmenopausal Women
Kiefer et al.
Psychosom. Med. 2008;70:845-849.
ABSTRACT | FULL TEXT  

Selecting Among Second-Step Antidepressant Medication Monotherapies: Predictive Value of Clinical, Demographic, or First-Step Treatment Features
Rush et al.
Arch Gen Psychiatry 2008;65:870-880.
ABSTRACT | FULL TEXT  

Developing the evidence for evidence-based practice
Rush
CMAJ 2008;178:1313-1315.
FULL TEXT  

Overweight children find food more reinforcing and consume more energy than do nonoverweight children
Temple et al.
Am. J. Clin. Nutr. 2008;87:1121-1127.
ABSTRACT | FULL TEXT  

A Randomized Intervention Trial to Reduce the Lending of Used Injection Equipment Among Injection Drug Users Infected With Hepatitis C
Latka et al.
AJPH 2008;98:853-861.
ABSTRACT | FULL TEXT  

Team Sports for Overweight Children: The Stanford Sports to Prevent Obesity Randomized Trial (SPORT)
Weintraub et al.
Arch Pediatr Adolesc Med 2008;162:232-237.
ABSTRACT | FULL TEXT  

Effects of Fast Food Branding on Young Children's Taste Preferences
Robinson et al.
Arch Pediatr Adolesc Med 2007;161:792-797.
ABSTRACT | FULL TEXT  

A Word From Our Moderator
Deinum and van der Wilt
JAMA 2007;297:156-156.
FULL TEXT  

A Word From Our Moderator
Shrier
JAMA 2007;297:156-157.
FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2006 American Medical Association. All Rights Reserved.