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Risks of Dental Amalgam in Children—Reply
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In Reply: Our article did not state that there is no evidence of an association between exposure to mercury vapor released from amalgams and human health risks. To paraphrase Paracelsus,1 it is the dose that makes the poison. We reported that, at the levels of amalgam exposure experienced by the children enrolled in the New England Children's Amalgam Trial, we did not observe any adverse effects on neuropsychological or renal function.
The outcomes reported were those identified at the outset of the trial as the primary end points. Drs Pigatto and Meroni are correct that, for a subgroup of the children who participated in the trial, measurements of immune responsiveness were carried out.2 The results of treatment group comparisons of these end points will be reported when they are available.
Financial Disclosures: None reported.
Sonja A. McKinlay, PhD
smckinlay@neriscience.com
New England Research Institutes, Inc
Watertown, Mass
1. Deichmann WB, Henschler D, Holmsted B, Keil G. What is there that is not poison? a study of the Third Defense by Paracelsus. Arch Toxicol. 1986;58:207-213.
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2. Children's Amalgam Trial Study Group. The Children's Amalgam Trial: design and methods. Control Clin Trials. 2003;24:795-814.
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JAMA. 2006;296:1461.
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