You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 296 No. 14, October 11, 2006 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Letters
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Contact me when this article is cited
 Related Content
 •Related articles
 •Similar articles in JAMA
 Topic Collections
 •Diabetes Mellitus
 •Tobacco
 •Nutritional and Metabolic Disorders, Other
 •Alert me on articles by topic

Glucose Fluctuations and Oxidative Stress

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: The study of activation of oxidative stress in patients with type 2 diabetes by Dr Monnier and colleagues1 identifies an interesting association between glycemic variability and oxidative stress. However, it is important to highlight some limitations of the tools used in this study and the data reported.

Continuous glucose monitoring systems (CGMSs) may be inaccurate or even intermittently fail to record. The authors report the accuracy of CGMSs for a single fasting time point but do not report whether a minimum accuracy criterion was applied prior to accepting a 24-hour glucose profile, such as a maximum permitted mean relative absolute difference between all concurrent CGMSs and capillary glucose measurements, or a maximum gap in the CGMS recording.

The study examined only 1 marker of oxidative stress, urinary 8-iso prostaglandin F2{alpha} (8-iso-PGF2{alpha}). Although most studies demonstrate elevated urinary 8-iso-PGF2{alpha} in patients with diabetes, some studies have indicated . . . [Full Text of this Article]

Kevin B. Moore, MD
kmoore30@jhmi.edu
Division of Endocrinology and Metabolism
Johns Hopkins University
Baltimore, Md


RELATED ARTICLES

Glucose Fluctuations and Oxidative Stress—Reply
Louis Monnier, Emilie Mas, Christine Ginet, Françoise Michel, Laetitia Villon, Jean-Paul Cristol, and Claude Colette
JAMA. 2006;296(14):1730-1731.
EXTRACT | FULL TEXT  

Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 Diabetes
Louis Monnier, Emilie Mas, Christine Ginet, Françoise Michel, Laetitia Villon, Jean-Paul Cristol, and Claude Colette
JAMA. 2006;295(14):1681-1687.
ABSTRACT | FULL TEXT  






HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2006 American Medical Association. All Rights Reserved.