 |
|
Translation of Research Evidence From Animals to Humans
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
To the Editor: Most medical therapies in use today were initially developed and tested in animals,1 yet animal experiments often fail to replicate when tested in rigorous human trials.2-3 We conducted a systematic review to determine how often highly cited animal studies translate into successful human research.
Methods
The 7 leading scientific journals by citation impact factor (Journal Citation Reports, Thomson Scientific, Philadelphia, Pa, 2004) that regularly publish original animal studies were searched: Science, Nature, Cell, Nature Medicine, Nature Genetics, Nature Immunology, and Nature Biotechnology. Articles with more than 500 citations were retrieved under the assumption that such prominent findings would more likely be tested in subsequent human trials.4 A total of 2000 articles published between 1980 and 2000 were screened, reflecting advances in molecular biology and recombinant genetics. Articles were included if they investigated a preventive or therapeutic intervention in an in vivo animal model. When there . . . [Full Text of this Article]
Daniel G. Hackam, MD
Daniel.Hackam@ices.on.ca
Donald A. Redelmeier, MD, MSHSR
Department of Medicine
University of Toronto
Toronto, Ontario
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Intermittent pneumatic compression in fracture and soft-tissue injuries healing
Khanna et al.
Br Med Bull 2008;0:ldn024v1-10.
ABSTRACT
| FULL TEXT
Translation of Genetic Discoveries into Clinical Therapies
Hackam and Hackam
ANN INTERN MED 2008;148:246-247.
FULL TEXT
Repair in the central nervous system
FitzGerald and Fawcett
J Bone Joint Surg Br 2007;89-B:1413-1420.
ABSTRACT
| FULL TEXT
Translating animal research into clinical benefit
Hackam
BMJ 2007;334:163-164.
FULL TEXT
|
