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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: The clinical trial of G-CSF therapy for patients with AMI by Dr Zohlnhöfer and colleagues¹ showed that when compared with placebo, the therapy had no benefit in terms of infarct size and left ventricular function. Another trial also failed to show any functional improvement after AMI with G-CSF treatment.² These results suggest that there might be some unknown mechanisms undermining the therapy.

A recent basic research study might provide an explanation for these results. Katayama et al³ found evidence that the sympathetic nervous system regulates hematopoietic stem cell mobilization in bone marrow. In their experiments, G-CSF–induced stem cell mobilization was stimulated by ₂-adrenergic agonists but was suppressed by -blockers. These findings suggest that -blockers might have attenuated the effect of G-CSF in the patients studied by Zohlnhöfer et al by affecting the stem cell mobilization process. The authors reported that 100% of patients in the G-CSF group . . . [Full Text of this Article]

Jaewon Oh
drjaewonoh@gmail.com
Yonsei University College of Medicine
Seoul, Korea

Dae Hyun Kim, MD, MPH
Jefferson Medical College
Philadelphia, Pa

Hyunseok Kang, MD
Yonsei University Graduate School of Public Health
Seoul, Korea

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