Funding of Clinical Trials
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To the Editor: In their study of reported outcomes in major cardiovascular trials, Dr Ridker and Mr Torres1 found that clinical trials funded by for-profit organizations were more likely to report positive findings than those funded by not-for-profit organizations, which were more likely to report results that were negative. One explanation not considered in their discussion is the possibility that the private sector is better able to predict a positive outcome.
The National Institutes of Health funds projects based on the decisions of review committees made up of academic researchers. Such groups may promote studies of public health issues that are neglected by industry because of unprofitable treatments or populations, or test scientifically viable hypotheses without patent-protected sponsors. However, committees of investigators may not safeguard taxpayer dollars in order to maximize a return on investment with the same alacrity as a project officer in a drug or device company who . . . [Full Text of this Article]
Steven Borzak, MD
sborzak1@hotmail.com
Nova Southeastern College of Medicine
Atlantis, Fla
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Reported Outcomes in Major Cardiovascular Clinical Trials Funded by For-Profit and Not-for-Profit Organizations: 2000-2005
Paul M Ridker and Jose Torres
JAMA. 2006;295(19):2270-2274.
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