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Mike Mitka

JAMA. 2006;296:2193.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Most physicians are aware of the positive and negative consequences associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), but the American Gastroenterology Association (AGA) believes clinicians should be more familiar than they currently are about the risks associated with specific NSAIDs, the magnitude of risks, and ways to reduce such risks.

To that end, the AGA has compiled a set of recommendations from a cross-disciplinary panel to serve as a template for treating patients with NSAIDs, from aspirin to the cyclooxygenase 2 (COX-2) inhibitors (Wilcox CM et al. Clin Gastroenterol Hepatol. 2006;4:1082-1089). The document focuses on gastrointestinal toxicity associated with NSAID use but also highlights cardiovascular risks and benefits associated with these medications.

Risks of gastrointestinal or cardiovascular complications are associated with specific nonsteroidal anti-inflammatory drugs.

The issue of NSAID use "has gotten hot with the troubles surrounding coxibs [COX-2 inhibitors]," said C. Mel Wilcox, MD, . . . [Full Text of this Article]