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In Reply: Dr Schobersberger and colleagues correctly draw attention to some of the differences between the conditions in our study and those of a long-haul flight. The aim of our study was to assess the effect on hemostatic parameters of hypobaric hypoxia, equivalent to that which might be experienced on a long-haul flight, after controlling for any effects due to prolonged sitting or circadian variation. We did not attempt to replicate all of the conditions of a long-haul flight and the absence of any apparent effect of hypobaric hypoxia on hemostasis should not be taken to imply that air travel is without risk of venous thrombosis. Data from a recent large case-control study¹ indicate that long-haul air travel, with a flight duration in excess of 4 hours, is associated with a 2-fold increase in the risk of deep vein thrombosis or pulmonary embolism. The overall risk is similar during travel . . . [Full Text of this Article]

William D. Toff, MD
w.toff@le.ac.uk

Alison H. Goodall, PhD
Department of Cardiovascular Sciences
University of Leicester
Leicester, England

Michael Greaves, MD
Department of Medicine and Therapeutics
University of Aberdeen
Aberdeen, Scotland

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