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Genetics Research on Smoking Suggests Caution About Expectations

Chris Carlsten, MD, MPH; Wylie Burke, MD, PhD

JAMA. 2006;296:2480-2482.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The number of DNA-based tests available for use in clinical care has rapidly increased over the past decade, and this trend has implications for public health and preventive medicine. In the 1990s, Coughlin¹ described an "emerging paradigm of disease prevention—the identification and modification of environmental risk factors among persons susceptible to disease due to genotype." This optimistic vision of genetically based prevention was applied to lung cancer when Collins introduced "John," who joins a support group of persons at genetically high risk of complications of smoking and thereby kicks the habit.² Yet a closer look raises questions about public health and research priorities.³

Clearly, smoking-induced lung cancer, first described by Rottman⁴ in 1898, continues to be a major public health concern. Lung cancer is the leading cause of cancer-related death in the United States.⁵ Smoking cessation reduces the chance of . . . [Full Text of this Article]

Author Affiliations: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Occupational and Environmental Medicine Program (Dr Carlsten), and Department of Medical History and Ethics (Dr Burke), University of Washington, Seattle.

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