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The Incidentalome
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To the Editor: A growing body of literature focuses on how to handle incidental findings, ranging from unexpected masses visualized in radiological imaging to unanticipated findings in the course of surgery or other treatments. In their Commentary, Dr Kohane and colleagues1 appropriately point to the potential for incidental findings in genome-scale screening. However, they fail to make a critical distinction between incidental findings in human subject research and incidental findings in the course of clinical treatment.
When incidental findings arise in clinical treatment, the treating physician, whose motivation is to address all clinical needs of the patient, can readily trigger consultation and referral. Incidental findings in research, however, raise a series of questions: whether researchers are obligated to look beyond the variables or field under study to unexpected findings of potential clinical significance, whether researchers should then seek a consultation to verify that there is a finding of concern, whether . . . [Full Text of this Article]
Susan M. Wolf, JD
swolf@umn.edu
Jeffrey P. Kahn, PhD, MPH;
Frances P. Lawrenz, PhD
University of Minnesota
Minneapolis
Charles A. Nelson, PhD
Harvard Medical School
Children's Hospital
Boston, Mass
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