 |
|
The Incidentalome—Reply
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In Reply: In our Commentary, we explicitly focused on the clinical use of genomic test panels and not on their use for discovery in population studies. For the latter studies we firmly believe that a broad, comprehensive, multivariate approach with careful analysis is desirable. Measuring thousands of genetic variants in large populations can establish the probabilistic dependencies on which rational sequential testing strategies for clinical diagnostics can be developed.
Notwithstanding, the ethical concerns about incidental findings raised by Dr Wolf and colleagues are indeed ones that researchers in population genomics increasingly face and for which guidance and regulation are either incomplete or unsatisfactory. We anticipate as much effort in the coming decades in managing the incidentalome discovered during research as the incidentalome uncovered in the course of clinical care.
In this context, we find ourselves with some ambivalence regarding the perspective articulated by Dr Kruer. It is certainly the case . . . [Full Text of this Article]
Isaac S. Kohane, MD, PhD
isaac_kohane@harvard.edu
Harvard Medical School
Boston, Mass
Daniel R. Masys, MD
Vanderbilt University School of Medicine
Nashville, Tenn
Russ B. Altman, MD, PhD
Stanford University
Stanford, Calif
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
The Incidentalome
Susan M. Wolf, Jeffrey P. Kahn, Frances P. Lawrenz, and Charles A. Nelson
JAMA. 2006;296(23):2800-2801.
EXTRACT
| FULL TEXT
The Incidentalome
Michael Kruer
JAMA. 2006;296(23):2801.
EXTRACT
| FULL TEXT
RELATED ARTICLE
The Incidentalome: A Threat to Genomic Medicine
Isaac S. Kohane, Daniel R. Masys, and Russ B. Altman
JAMA. 2006;296(2):212-215.
EXTRACT
| FULL TEXT
|
