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Richard B. Lipton, MD; Marcelo E. Bigal, MD, PhD

JAMA. 2006;296:332-333.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The association between migraine and ischemic vascular events has been debated for many years.^1-2 Migraine with aura is now well established as a risk factor for ischemic stroke, particularly among women.³ The relationship of migraine and ischemic cardiac disease has been less clear. Several reports have demonstrated an association between migraine, particularly migraine with aura, and angina,⁴ although convincing evidence linking migraine to ominous cardiovascular outcomes such as myocardial infarction or coronary revascularization has not been available.

The study by Kurth and colleagues in this issue of JAMA changes this landscape.⁵ The investigators examined the relationship between migraine and a range of prospectively determined cardiovascular end points using data from the Women's Health Study, a cohort study that followed nearly 28 000 women for an average of more than 10 years. Their primary composite end point, major cardiovascular disease (CVD), included nonfatal . . . [Full Text of this Article]

Author Affiliations: Departments of Epidemiology and Population Health (Dr Lipton) and Neurology (Drs Lipton and Bigal) Albert Einstein College of Medicine, and the Montefiore Headache Center (Drs Lipton and Bigal), Bronx, NY.

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