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Coffee, Myocardial Infarction, and CYP Nomenclature
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To the Editor: In their study of coffee, CYP1A2 genotype, and myocardial infarction risk, Ms Cornelis and colleagues1 concluded that carriers of the CYP1A2*1F allele, which they define as a slow allele for caffeine metabolism, have an increased risk of nonfatal myocardial infarction compared with carriers of the CYP1A2*1A allele. The increased risk associated with coffee intake was only observed among the carriers of the *1F allele, and the effect was similar in smokers and nonsmokers.
There are 2 major problems related to this study. First, we believe that the authors' definition of the alleles is incorrect. According to the official names determined by the international CYP Allele Nomenclature Committee,2 and commonly used in articles published in this research field since the CYP1A2 nomenclature was accepted in 2001, the "reference" –163 position has a cytosine and thus the wild-type (consensus) name for the CYP1A2*1A allele is "–163C." By measuring "the . . . [Full Text of this Article]
Magnus Ingelman-Sundberg, PhD, BScM
magnus.ingelman-sundberg@ki.se
Sarah C. Sim, MSc
Department of Physiology and Pharmacology
Karolinska Institutet
Stockholm, Sweden
Daniel W. Nebert, MD
Department of Environmental Health
University of Cincinnati Medical Center
Cincinnati, Ohio
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