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Coffee, Myocardial Infarction, and CYP Nomenclature—Reply
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In Reply: Dr Ingelman-Sundberg, Ms Sim, and Dr Nebert claim that our definition of the CYP1A2 alleles is incorrect because it is not in accordance with the Human Cytochrome P450 (CYP) Allele Nomenclature Committee's definition.1 The confusion over the naming stems from that committee's decision to change the name of the highly inducible allele from CYP1A2*1A, as described in the original publication by Sachse et al,2 to CYP1A2*1F. In that article, the highly inducible allele has the "A" nucleotide at position +734 (also referred to as position –163). We indicated in our article that we detected the A C polymorphism described by the widely accepted dbSNP reference number (rs762551) on the National Center for Biotechnology Information (NCBI) Web site,3 and we defined the allele containing the "A" nucleotide as CYP1A2*1A. Despite the claims of Ingelman-Sundberg et al, recent studies4-6 continue to define the highly . . . [Full Text of this Article]
Marilyn C. Cornelis, BSc;
Ahmed El-Sohemy, PhD
a.el.sohemy@utoronto.ca
Department of Nutritional Sciences
University of Toronto
Toronto, Ontario
Edmond K. Kabagambe, PhD;
Hannia Campos, PhD
Department of Nutrition
Harvard School of Public Health
Boston, Mass
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Coffee, Myocardial Infarction, and CYP Nomenclature
Magnus Ingelman-Sundberg, Sarah C. Sim, and Daniel W. Nebert
JAMA. 2006;296(7):764-765.
EXTRACT
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Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
Marilyn C. Cornelis, Ahmed El-Sohemy, Edmond K. Kabagambe, and Hannia Campos
JAMA. 2006;295(10):1135-1141.
ABSTRACT
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