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Birth Spacing and Adverse Perinatal Outcomes—Reply
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In Reply: Drs Scheepers and Braat offer the alternative hypothesis that the effects on perinatal outcomes that were observed in our study could be secondary to subfertility of women rather than a consequence of long interpregnancy interval. We do not believe that this explanation is supported by the evidence that they cite. First, the study by Yasmin et al1 included women with multiple pregnancies, which are associated with a higher risk of adverse perinatal outcomes. Moreover, in that study there was no control group, and no potential confounding factors were taken into account. Second, in the study by Thomson et al,2 the majority of subfertile women were primiparous (69%), and there was no information on interpregnancy intervals of those who were multiparous, so that their results were not adjusted for this variable. In addition, 34% of the subfertility cases were attributed to male-factor infertility. Third, the findings of Thomson et . . . [Full Text of this Article]
Agustín Conde-Agudelo, MD, MPH
condeagu@uniweb.net.co
Centro de Estudios e Investigación en Salud
Department of Obstetrics and Gynecology
Fundación Santa Fe de Bogotá
Bogotá, Colombia
Anyeli Rosas-Bermúdez, MPH
Department of Biostatistics
Universidad Autonoma de Occidente
Cali, Colombia
Ana Cecilia Kafury-Goeta, MD
Clinica Materno-Infantil Los Farallones
Cali, Colombia
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