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In Reply: In response to Dr Mahid and colleagues, although we did not have access to EMBASE, we did conduct bibliographic searches of review articles and included abstracts from the "grey literature" through these searches. For example, the results of Baker et al were published only in abstract form.¹ We agree that searching this type of literature is particularly important for finding negative studies, because positive findings are more likely to be published in peer-reviewed journals indexed by MEDLINE. In the case of our pooled analysis, we identified no association between folic acid supplementation and the risk of cardiovascular diseases or all-cause mortality.

We have searched the EMBASE database using identical terms and limits and identified 240 references that were screened; only 1 additional study met our inclusion criteria.² This study found no difference between the folic acid supplementation group and control group in rate of in-stent restenosis after percutaneous . . . [Full Text of this Article]

Lydia A. Bazzano, MD, PhD
lbazzano@tulane.edu

Kristi Reynolds, PhD
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine

Kevin N. Holder, MD
Department of Medicine
Tulane University School of Medicine

Jiang He, MD, PhD
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine
New Orleans, La

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