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Tracy Hampton, PhD

JAMA. 2007;297:1645.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A warning from the US Food and Drug Administration (FDA) has linked pioglitazone (Actos), a thiazolidinedione prescribed for the treatment of type 2 diabetes, with an increased rate of arm, hand, and lower leg fractures among women. The action comes less than a month after a similar warning about excess fractures in women taking rosiglitazone (Avandia), another drug in the same class. The increased risk did not appear in men.

While the drugs remain on the market and continue to be valuable tools in physicians' therapeutic armamentarium against type 2 diabetes, investigators are striving to determine the mechanism of these effects and which patients are at increased risk.

(Photo credit: Simon Fraser/http://www.sciencesource.com)

RECENT WARNINGS

Thiazolidinediones, which lower insulin resistance, are often prescribed when other medications have failed to reduce blood glucose levels in patients with type 2 diabetes. As with a variety of other drugs, adverse effects . . . [Full Text of this Article]

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