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Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
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To the Editor: Older adults are more likely to be hospitalized and are at risk for functional decline during hospitalization. Bed rest may contribute to this functional compromise. We examined the effect of 10 days of bed rest in healthy older men and women on skeletal muscle protein synthesis, nitrogen balance, lean tissue mass, and lower extremity strength.
Methods
Twelve healthy older adults who were moderately active (mean [SD] age, 67 [5] years; 50% women) were recruited from advertisements and compensated for their participation. They remained in bed continuously for 10 days, except for toileting, and they consumed a eucaloric diet providing the recommended dietary allowance for protein (0.8 g/kg of protein per day). Measurements before and after bed rest included the fractional muscle protein synthesis rate over 24 hours, lean body mass by dual-energy x-ray absorptiometry (DEXA, Hologic Inc, Waltham, Mass), and unilateral knee extension strength (Cybex Strength Systems, Ronkonkoma, . . . [Full Text of this Article]
Patrick Kortebein, MD;
Arny Ferrando, PhD;
Juan Lombeida, MD;
Robert Wolfe, PhD
University of Arkansas for Medical Sciences
William J. Evans, PhD
evanswilliamj@uams.edu
Central Arkansas Veterans Healthcare System
Little Rock
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