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Tracy Hampton, PhD

JAMA. 2007;297:1870.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

New research has identified a gene that, when mutated, may suppress colorectal cancer. Scientists from Thomas Jefferson University, in Philadelphia, found that when mice that are prone to developing polyps in the digestive tract possess only 1 copy of the mutated gene (mice with 2 copies of the mutation die during embryonic development), the incidence of intestinal polyps is reduced by about 90% (Baran AA et al. Genome Res. doi:10.1101/gr .6089707 [published online ahead of print March 26, 2007]).

The newly discovered mutation disrupts a gene called Atp5a1 that encodes a subunit of the energy-producing enzyme adenosine triphosphate synthase. The findings have particular clinical relevance because the human version of the gene (ATP5A1) is located in a region of chromosome 18 that is often altered in colon tumors.

"The ATP5A1 gene may provide a novel target to aid in diagnostics, prevention and/or treatment of . . . [Full Text of this Article]

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