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Tracy Hampton, PhD

JAMA. 2007;297:2188.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Researchers at the National Cancer Institute and Johns Hopkins University, in Baltimore, have determined that children and young adults with sarcoma are at increased risk of having a venous thromboembolic event (TE) (Paz-Priel I et al. J Clin Oncol. 2007;25:1519-1524).

The study was based on patient records for 122 children and young adults treated for sarcoma in the Pediatric Oncology Branch of the National Cancer Institute between 1980 and 2002. Over the 22-year study period, 16% of children and young adults with sarcoma developed a TE. In addition, 23% of patients with sarcoma whose cancer metastasized developed a TE compared with 10% of patients with localized cancer, a finding that suggests an association between tumor burden and the risk of TE.

Scientists suspect that cancer creates an environment that is conducive to thrombosis because of tumor cells' propensity to promote coagulation and to trigger inflammation. In . . . [Full Text of this Article]