This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related letters  • Related article  • Similar articles in JAMA  Topic Collections  • Diabetes Mellitus  • Aging/ Geriatrics  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Discussing a 74-year-old woman with diabetes, Dr Abrahamson¹ noted that " . . . no studies have evaluated the impact of intensive glucose control in individuals older than 60 years."¹ He could have added that no studies have evaluated the effect of intensive control with rosiglitazone or the effect of this combination of antidiabetic drugs. Nonetheless, when this patient taking a combination of metformin, glyburide, and rosiglitazone had a HbA_1C value of 6.9%, the rosiglitazone dose was doubled, and the discussion centered on the variety of other drugs that can be added later when needed for intensive control.

The actual evidence for the benefits of intensive glucose control in any group of patients with type 2 diabetes mellitus is limited, as shown in a review of all randomized clinical trials.² One effect of intensive glucose control, reported in UKPDS 34, was significantly increased risk of diabetes-related death associated with early addition . . . [Full Text of this Article]

Thomas E. Finucane, MD
tfinucan@jhmi.edu
Division of Geriatric Medicine & Gerontology
Johns Hopkins Bayview Medical Center
Baltimore, Md

RELATED LETTERS

Intensive Glucose Control in Elderly Adults
Rodney A. Hayward, Timothy P. Hofer, and Sandeep Vijan
JAMA. 2007;297(20):2195.
EXTRACT | FULL TEXT  

Intensive Glucose Control in Elderly Adults—Reply
Martin J. Abrahamson
JAMA. 2007;297(20):2196.
EXTRACT | FULL TEXT  

RELATED ARTICLE

A 74-Year-Old Woman With Diabetes
Martin J. Abrahamson
JAMA. 2007;297(2):196-204.
ABSTRACT | FULL TEXT